Ninian J. Blackburn

Professor, Department of
Environmental and Biomolecular Systems

Ph.D., Inorganic Chemistry; University of Dundee, Scotland, U.K., 1975

• Postdoctoral studies in biophysical chemistry with Howard S. Mason at the
  Oregon Health Sciences University and Peter F. Knowles at Leeds, 1974-79
• Lecturer in Inorganic Chemistry, University of Manchester Institute
  of Science and Technology, 1979-87
• Visiting Lecturer, University of Sydney, 1987

Structure and function of oxidase and oxygenase metalloenzymes; spectroscopy of metal sites in proteins with emphasis on EPR, EXAFS, absorption edge, and FTIR spectroscopies; coordination chemistry and biochemistry of copper. Biochemistry of metal trafficking in cells.

Bagai, I.; Rensing, C.; Blackburn, N. J.; McEvoy, M. M. (2008) Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. Biochemistry, 47(44), 11408-11414.

Barry, A. N.; Blackburn, N. J. (2008) A selenocysteine variant of the human copper chaperone for superoxide dismutase. A Se-XAS Probe of Cluster Composition at the Domain 3-Domain 3 Dimer Interface. Biochemistry, 47(17), 4916-4928.

Bagai, I.; Liu, W.; Rensing, C.; Blackburn, N. J.; McEvoy, M. M. (2007) Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system. Journal of Biological Chemistry, 282(49), 35695-35702.

Loftin, I. R.; Franke, S.; Blackburn, N. J.; McEvoy, M. M. (2007) Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy. Protein Science, 16(10), 2287-2293.

Stasser, J. P.; Siluvai, G. S.; Barry, A. N.; Blackburn, N. J. (2007) A Multinuclear copper(I) cluster forms the dimerization interface in copper-loaded human copper chaperone for superoxide dismutase. Biochemistry, 46(42), 11845-11856.

Himes, R. A.; Park, G. Y.; Barry, A. N.; Blackburn, N. J.; Karlin, K. D. (2007) Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry. Journal of the American Chemical Society, 129(17), 5352-5353.

Evans, J. P.; Blackburn, N. J.; Klinman, J. P. (2006) The catalytic role of the copper ligand H172 of peptidylglycine alpha -hydroxylating monooxygenase: a kinetic study of the H172A mutant. Biochemistry, 45(51), 15419-15429.

Bauman, A. T.; Ralle, M.; Blackburn, N. J. (2007) Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor. Protein Expression and Purification, 51(1), 34-38.

Berrington-Gonzalez, A.; Urban, M. I.; Sitas, F.; Blackburn, N.; Hale, M.; Patel, M.; Ruff, P.; Sur, R.; Newton, R.; Beral, V. (2006) Antibodies against six human herpesviruses in relation to seven cancers in black South Africans: a case control study. Infectious Agents and Cancer, 1;2-10.

Bauman, A. T.; Jaron, S.; Yukl, E. T.; Burchfiel, J. R.; Blackburn, N. J. (2006) pH dependence of peptidylglycine monooxygenase. Mechanistic implications of Cu-methionine binding dynamics. Biochemistry, 45(37), 11140-11150.

De, M.; Bell, J.; Blackburn, N. J.; Mains, R. E.; Eipper, B. A. (2006) Role for an essential tyrosine in peptide amidation. Journal of Biological Chemistry, 281(30), 20873-20882.

Bauman, A. T.; Yukl, E. T.; Alkevich, K.; McCormack, A. L.; Blackburn, N. J. (2006) The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate. Journal of Biological Chemistry, 281(7), 4190-4198.

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